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低密度脂蛋白受體5樣蛋白抗體
  • 產(chǎn)品貨號：
    BN40315R
  • 中文名稱：
    低密度脂蛋白受體5樣蛋白抗體
  • 英文名稱：
    Rabbit anti-LRP5L Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40315R-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Mouse,Rat,Chicken,Sheep) 推薦應用：WB,ELISA

  • BN40315R-200ul

    200ul

    ￥3490.00

    交叉反應：Human(predicted:Mouse,Rat,Chicken,Sheep) 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱LRP5L
中文名稱低密度脂蛋白受體5樣蛋白抗體
別    名Low-density lipoprotein receptor-related protein 5-like protein; LRP-5-like; LRP5L; GP330; LRP5L_HUMAN.  
研究領域細胞生物  發(fā)育生物學  細胞周期蛋白  轉錄調(diào)節(jié)因子  表觀遺傳學  細胞膜蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human,  (predicted: Mouse, Rat, Chicken, Sheep, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human LRP5L:101-200/252 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Members of the LDL receptor gene family, including LDLR (low density lipo-protein receptor), LRPs (low density lipoprotein related proteins), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Of the known family members, LRP5 is most closely related to LRP1. However, LRP5 has a unique organization of EGF and LDLR repeats compared to other LDLR family members and likely represents a new category in this family. LRP is expressed in rat tibia, specifically in areas of the bone that are involved in remodeling. LRP5 is a Wnt coreceptor that binds to Axin and regulates the canonical Wnt signaling pathway. LRP5 affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). LRP5L is a related protein that exists as two isoforms produced by alternative splicing.

Similarity:
Contains 5 LDL-receptor class B repeats.

SWISS:
A4QPB2

Gene ID:
91355

Database links:

Entrez Gene: 91355 Human

SwissProt: A4QPB2 Human

Unigene: 634058 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.