貨號
產(chǎn)品規(guī)格
售價
備注
BN40315R-100ul
100ul
¥2360.00
交叉反應:Human(predicted:Mouse,Rat,Chicken,Sheep) 推薦應用:WB,ELISA
BN40315R-200ul
200ul
¥3490.00
交叉反應:Human(predicted:Mouse,Rat,Chicken,Sheep) 推薦應用:WB,ELISA
產(chǎn)品描述
英文名稱 | LRP5L |
中文名稱 | 低密度脂蛋白受體5樣蛋白抗體 |
別 名 | Low-density lipoprotein receptor-related protein 5-like protein; LRP-5-like; LRP5L; GP330; LRP5L_HUMAN. |
研究領域 | 細胞生物 發(fā)育生物學 細胞周期蛋白 轉錄調(diào)節(jié)因子 表觀遺傳學 細胞膜蛋白 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應 | Human, (predicted: Mouse, Rat, Chicken, Sheep, ) |
產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 28kDa |
細胞定位 | 細胞核 細胞漿 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human LRP5L:101-200/252 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
PubMed | PubMed |
產(chǎn)品介紹 | Members of the LDL receptor gene family, including LDLR (low density lipo-protein receptor), LRPs (low density lipoprotein related proteins), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Of the known family members, LRP5 is most closely related to LRP1. However, LRP5 has a unique organization of EGF and LDLR repeats compared to other LDLR family members and likely represents a new category in this family. LRP is expressed in rat tibia, specifically in areas of the bone that are involved in remodeling. LRP5 is a Wnt coreceptor that binds to Axin and regulates the canonical Wnt signaling pathway. LRP5 affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). LRP5L is a related protein that exists as two isoforms produced by alternative splicing. Similarity: Contains 5 LDL-receptor class B repeats. SWISS: A4QPB2 Gene ID: 91355 Database links: Entrez Gene: 91355 Human SwissProt: A4QPB2 Human Unigene: 634058 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |