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鋅指蛋白201抗體
  • 產(chǎn)品貨號：
    BN40317R
  • 中文名稱：
    鋅指蛋白201抗體
  • 英文名稱：
    Rabbit anti-Zic1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN40317R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Pig,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40317R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Pig,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Zic1
中文名稱鋅指蛋白201抗體
別    名ZNF201; Odd paired homolog Drosophila; Zic 1; ZIC; Zic family member 1 (odd-paired Drosophila homolog); Zic family member 1; Zic protein member 1; zic1; ZIC1_HUMAN; Zinc finger protein 201; Zinc finger protein of the cerebellum 1; Zinc finger protein ZIC 1; Zinc finger protein ZIC1; ZNF 201.  



研究領(lǐng)域神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  鋅指蛋白  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Chicken, Pig, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量48kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Zic1:201-286/447 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Zic1 is a C2H2 zinc finger transcription factor that controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation. Zic1 determines the cerebellar folial pattern by influencing proliferation in the external germinal layer (EGL). Zic1 can bind and transactivate the apolipoprotein E gene.This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3.

Function:
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.

Subunit:
Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation

Subcellular Location:
Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression.

Tissue Specificity:
CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.

Similarity:
Belongs to the GLI C2H2-type zinc-finger protein family.
Contains 5 C2H2-type zinc fingers.

SWISS:
Q15915

Gene ID:
7545

Database links:

Entrez Gene: 7545 Human

Entrez Gene: 22771 Mouse

Entrez Gene: 64618 Rat

Omim: 600470 Human

SwissProt: Q15915 Human

SwissProt: P46684 Mouse

Unigene: 598590 Human

Unigene: 647962 Human

Unigene: 335350 Mouse

Unigene: 477226 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications