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谷氨酸受體δ1/GluR-δ1抗體
  • 產(chǎn)品貨號(hào)：
    BN40351R
  • 中文名稱：
    谷氨酸受體δ1/GluR-δ1抗體
  • 英文名稱：
    Rabbit anti-GRID1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40351R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Cow,Horse,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40351R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Cow,Horse,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱GRID1
中文名稱谷氨酸受體δ1/GluR-δ1抗體
別    名GluR delta 1; GluR delta 1 subunit; GluR delta-1 subunit; Glutamate receptor delta 1 subunit; Glutamate receptor delta-1 subunit; Glutamate receptor ionotropic delta 1; GRID 1; Grid1; GRID1_HUMAN; KIAA1220.  
研究領(lǐng)域神經(jīng)生物學(xué)  通道蛋白  細(xì)胞膜受體  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量110kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GRID1:501-600/1009 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Glutamate receptors mediate most excitatory neurotransmissions in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are divided into two categories, namely NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors consist of seven structurally related subunits, designated GluR-1 to -7, and are primarily responsible for fast excitatory neurotransmissions carried out by glutamate. GluR-delta 1 (Glutamate receptor delta-1 subunit), also known as GRID1, is a multi-pass membrane protein that belongs to the kainate/AMPA receptor family and is expressed primarily in the brain. Localized to the cell junction and the postsynaptic cell membrane, GluR-delta 1 functions as a glutamate receptor that regulates synaptic transmissions in the central nervous system (CNS) and is thought to play an important role in synaptic plasticity. Defects in the gene encoding GluR-delta 1 are associated with schizophrenia, a chronic and severe brain disorder.

Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Subcellular Location:
Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity).

Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.

SWISS:
Q9ULK0

Gene ID:
2894

Database links:

Entrez Gene: 2894 Human

Entrez Gene: 14803 Mouse

GenBank: NP_060021.1 Human

Omim: 610659 Human

SwissProt: Q9ULK0 Human

SwissProt: Q61627 Mouse

Unigene: 530653 Human

Unigene: 121569 Mouse

Unigene: 413604 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.