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電壓門控性鉀通道Kv1.6抗體
  • 產(chǎn)品貨號：
    BN40355R
  • 中文名稱：
    電壓門控性鉀通道Kv1.6抗體
  • 英文名稱：
    Rabbit anti-Kv1.6 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40355R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Pig,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40355R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Pig,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Kv1.6
中文名稱電壓門控性鉀通道Kv1.6抗體
別    名HBK 2; HBK2; Human brain potassium channel 2; KCNA 6; Kcna6; KCNA6_HUMAN; KV1.6; potassium voltage gated channel shaker related subfamily member 6; potassium voltage gated channel subfamily A member 6; Potassium voltage-gated channel subfamily A member 6; voltage gated potassium channel protein Kv1.6; Voltage gated potassium channel subunit Kv1.6; Voltage-gated potassium channel HBK2; Voltage-gated potassium channel subunit Kv1.6.  
研究領(lǐng)域神經(jīng)生物學  通道蛋白  細胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Chicken, Pig, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量59kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Kv1.6:301-400/529 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.

Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit:
Heterotetramer of potassium channel proteins.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the potassium channel family.
A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.

SWISS:
P17658

Gene ID:
3742

Database links:

Entrez Gene: 3742 Human

Entrez Gene: 16494 Mouse

Entrez Gene: 64358 Rat

Omim: 176257 Human

SwissProt: P17658 Human

SwissProt: Q61923 Mouse

SwissProt: P17659 Rat

Unigene: 306190 Human

Unigene: 62535 Mouse

Unigene: 162791 Rat

Unigene: 60676 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.