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轉(zhuǎn)錄因子SOX7抗體
  • 產(chǎn)品貨號：
    BN40359R
  • 中文名稱：
    轉(zhuǎn)錄因子SOX7抗體
  • 英文名稱：
    Rabbit anti-SOX7 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40359R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40359R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱SOX7
中文名稱轉(zhuǎn)錄因子SOX7抗體
別    名MGC10895; SOX 7; SOX 7 transcription factor; sox7; SOX7 transcription factor; SOX7_HUMAN; SRY (sex determining region Y) box 7; SRY box 7; SRY sex determining region Y box 7; Transcription factor SOX 7; Transcription factor Sox-7; Transcription factor SOX7.  
研究領(lǐng)域細(xì)胞生物  發(fā)育生物學(xué)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SOX7:42-100/388 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

Function:
Transcriptional repressor. Binds to the DNA sequence 5'-AACAAT-3'.

Subunit:
Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.

Similarity:
Contains 1 HMG box DNA-binding domain.
Contains 1 Sox C-terminal domain.

SWISS:
Q9BT81

Gene ID:
83595

Database links:

Entrez Gene: 83595 Human

Entrez Gene: 20680 Mouse

Entrez Gene: 290317 Rat

Entrez Gene: 378665 Xenopus laevis

Omim: 612202 Human

SwissProt: Q9BT81 Human

SwissProt: P40646 Mouse

SwissProt: O42342 Xenopus laevis

Unigene: 709543 Human

Unigene: 42162 Mouse

Unigene: 1241 Xenopus laevis



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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