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血紅素氧合酶2抗體
  • 產(chǎn)品貨號(hào)：
    BN40364R
  • 中文名稱：
    血紅素氧合酶2抗體
  • 英文名稱：
    Rabbit anti-HO-2 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40364R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN40364R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱HO-2
中文名稱血紅素氧合酶2抗體
別    名Heme oxygenase (decycling) 2; Heme oxygenase (decyclizing) 2; HMOX 2; HMOX2; HMOX2 protein; HO 2; HO2; HMOX2_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  合成與降解  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HO-2:31-150/316 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Summary: catalyzes the conversion of heme to biliverdin; involved in cellular response to oxidative stress [SUBCELLULAR LOCATION] Microsome. Endoplasmic reticulum. [INDUCTION] Heme oxygenase 2 activity is non-inducible. [SIMILARITY] Belongs to the heme oxygenase family.

Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Subcellular Location:
Microsome. Endoplasmic reticulum.

Similarity:
Belongs to the heme oxygenase family.
Contains 2 HRM (heme regulatory motif) repeats.

SWISS:
P30519

Gene ID:
3163

Database links:

Entrez Gene: 510243 Cow

Entrez Gene: 479864 Dog

Entrez Gene: 3163 Human

Entrez Gene: 15369 Mouse

Entrez Gene: 100009523 Rabbit

Entrez Gene: 79239 Rat

Omim: 141251 Human

SwissProt: P30519 Human

SwissProt: O70252 Mouse

SwissProt: P43242 Rabbit

SwissProt: P23711 Rat

Unigene: 284279 Human

Unigene: 272866 Mouse

Unigene: 10241 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解（Synthesis and Degradation）
血紅素氧合酶是目前發(fā)現(xiàn)生物體內(nèi)最易被誘導(dǎo)產(chǎn)生的抗氧化酶類，其抗氧化作用與它的催化分解產(chǎn)物即膽綠素、膽紅素、NO、鐵離子和鐵蛋白有關(guān)。
血紅素氧合酶-2基因缺失對(duì)血紅素誘導(dǎo)的氧化應(yīng)激性導(dǎo)致的組織損傷具有保護(hù)作用;選擇性抑制神經(jīng)元血紅素氧合酶-2基因的表達(dá)可減輕氧化應(yīng)激性組織細(xì)胞損傷.