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磷酸化δ連環(huán)蛋白抗體
  • 產品貨號：
    BN40402R
  • 中文名稱：
    磷酸化δ連環(huán)蛋白抗體
  • 英文名稱：
    Rabbit anti-phospho-delta 1 Catenin (Tyr228) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40402R-100ul

    100ul

    ￥2470.00

    交叉反應：Mouse(predicted:Human,Rat) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱phospho-delta 1 Catenin (Tyr228)
中文名稱磷酸化δ連環(huán)蛋白抗體
別    名delta 1 Catenin (phospho Y228); p-delta 1 Catenin (phospho Y228); Cadherin associated Src substrate; Cadherin-associated Src substrate; CAS; Catenin (cadherin associated protein) delta 1; Catenin delta 1; Catenin delta-1; CTND1_HUMAN; CTNND 1; CTNND; CTNND1; KIAA0384; p120; P120 CAS; p120 catenin; P120 CTN; p120(cas); p120(ctn); P120CAS; P120CTN.  
產品類型磷酸化抗體 
研究領域細胞生物  信號轉導  干細胞  轉錄調節(jié)因子  細胞骨架  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse,  (predicted: Human, Rat, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量108kDa
細胞定位細胞核 細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human delta 1 Catenin around the phosphorylation site of Tyr228:DN(p-Y)GS 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]

Function:
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway. May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Subunit:
Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.

Subcellular Location:
Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.

Tissue Specificity:
Expressed in vascular endothelium.

Post-translational modifications:
Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ.

Similarity:
Belongs to the beta-catenin family.
Contains 10 ARM repeats.

SWISS:
O60716

Gene ID:
1500

Database links:

Entrez Gene: 1500 Human

Entrez Gene: 12388 Mouse

Entrez Gene: 311163 Rat

Omim: 601045 Human

SwissProt: O60716 Human

SwissProt: P30999 Mouse

Unigene: 166011 Human

Unigene: 35738 Mouse

Unigene: 9435 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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