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F-box蛋白2抗體
  • 產(chǎn)品貨號：
    BN40408R
  • 中文名稱：
    F-box蛋白2抗體
  • 英文名稱：
    Rabbit anti-FBXO2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40408R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40408R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱FBXO2
中文名稱F-box蛋白2抗體
別    名F box gene 1; F box only protein 2; F box protein 2; F box protein only 2; F-box only protein 2; FBG 1; FBG1; Fbs 1; Fbs1; Fbs2; FBX 2; FBX2; FBX2_HUMAN; FBXO 2; FBXO2; Neural F box protein NFB42; Neural F-box protein, 42-KD, rat, homolog of; NFB 42; NFB42; OCP1; Prpl4.  
研究領域細胞生物  信號轉(zhuǎn)導  細胞周期蛋白  泛素  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Sheep, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human FBXO2:121-220/296 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹FBXO2 is a 296 amino acid protein that contains one F-box domain and one F-box associated domain. Functioning as a component of the SCF complex, FBXO2 is thought to recognize and bind to select phosphorylated proteins, thereby promoting their ubiquitination and subsequent degradation.

Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.

Subunit:
Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity).

Subcellular Location:
Cytoplasm. Microsome membrane.

Similarity:
Contains 1 F-box domain.
Contains 1 FBA (F-box associated) domain.

SWISS:
Q9UK22

Gene ID:
26232

Database links:

Entrez Gene: 26232 Human

Entrez Gene: 230904 Mouse

Entrez Gene: 85273 Rat

Omim: 607112 Human

SwissProt: Q9UK22 Human

SwissProt: Q80UW2 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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