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肢體畸形相關(guān)蛋白FMN1抗體
  • 產(chǎn)品貨號：
    BN40412R
  • 中文名稱：
    肢體畸形相關(guān)蛋白FMN1抗體
  • 英文名稱：
    Rabbit anti-FMN1 Polyclonal antibody
  • 品牌：
    Biorigin

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    產(chǎn)品規(guī)格

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  • BN40412R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40412R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱FMN1
中文名稱肢體畸形相關(guān)蛋白FMN1抗體
別    名FMN; Formin 1; Formin1; Formin-1; LD; Limb deformity protein homolog; FMN1_HUMAN.
研究領(lǐng)域細胞生物  信號轉(zhuǎn)導(dǎo)  細胞骨架  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Dog, Cow, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量157kDa
細胞定位細胞核 細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human FMN1/Formin 1:651-750/1419 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. In mice, the limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of proteins known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing Actin filament assembly. Formins co-localize with the actin cytoskeleton and can translocate into the cell cytosol and into the nucleus in an HGF-dependent manner. Vertebrate nuclear formins can control polarizing activity in limb buds through establishment of a Sonic hedgehog/FGF-4 feedback loop. Deficiency mutations at the mammalian ld locus lead to profound developmental defects in limb and kidney formation. The human Formin 1 and 2 genes map to chromosome 15q13.3 and 1q43, respectively.

Function:
FMN1 plays a role in the formation of adherens junction and the polymerization of linear actin cables. Interacts with alpha-catenin and may interact with tubulin.

Subunit:
Interacts with alpha-catenin and may interact with tubulin (By similarity).

Subcellular Location:
Nucleus. Cytoplasm. Cell junction, adherens junction; Peripheral membrane protein; Cytoplasmic side.

Post-translational modifications:
Phosphorylated on serine and possibly threonine residues (By similarity).

Similarity:
Belongs to the formin homology family. Cappuccino subfamily.
Contains 1 FH1 (formin homology 1) domain.
Contains 1 FH2 (formin homology 2) domain.

SWISS:
Q68DA7

Gene ID:
342184

Database links:

Entrez Gene: 342184 Human

Entrez Gene: 14260 Mouse

Omim: 136535 Human

SwissProt: Q68DA7 Human

SwissProt: Q05860 Mouse

Unigene: 657649 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.