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CRB2蛋白抗體
  • 產(chǎn)品貨號：
    BN40440R
  • 中文名稱：
    CRB2蛋白抗體
  • 英文名稱：
    Rabbit anti-CRB2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40440R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40440R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱CRB2
中文名稱CRB2蛋白抗體
別    名Crb2; CRUM2_HUMAN; Crumbs homolog 2 (Drosophila); Crumbs homolog 2; Crumbs-like protein 2; RP11-230L22.2.  
研究領(lǐng)域細胞生物  免疫學  神經(jīng)生物學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量100, 123, 131kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CRB2:701-800/1285 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹CRB2 is a 1,285 amino acid protein that contains three laminin G-like domains and 15 EGF-like domains and exists as multiple alternatively spliced isoforms that are either secreted or membrane bound. Expressed in kidney and retina, as well as in fetal eye and brain, CRB2 is thought to play a role in the morphogenesis of polarized cells and may be involved in DNA repair. Defects in the gene encoding CRB2 are associated with the pathogenesis of autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), the former of which refers to a group of diseases that lead to the degeneration of retinal photoreceptor cells, ultimately resulting in a loss of vision. The gene encoding CRB2 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.

Function:
May play a role in polarized cells morphogenesis.

Subcellular Location:
Secreted and Cell membrane.

Tissue Specificity:
Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart.

Similarity:
Belongs to the Crumbs protein family.
Contains 15 EGF-like domains.
Contains 3 laminin G-like domains.

SWISS:
Q5IJ48

Gene ID:
286204

Database links:

Entrez Gene: 286204 Human

Entrez Gene: 241324 Mouse

Entrez Gene: 366031 Rat

Omim: 609720 Human

SwissProt: Q5IJ48 Human

SwissProt: Q80YA8 Mouse

Unigene: 710092 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications