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兒茶酚O甲基移位酶抗體
  • 產(chǎn)品貨號：
    BN40461R
  • 中文名稱：
    兒茶酚O甲基移位酶抗體
  • 英文名稱：
    Rabbit anti-COMT Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40461R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Pig,Cow,Horse) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40461R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Pig,Cow,Horse) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱COMT
中文名稱兒茶酚O甲基移位酶抗體
別    名Catechol O methyltransferase; Catechol O-methyltransferase; COMT; COMT_HUMAN; EC 2.1.1.6.   
研究領域神經(jīng)生物學  信號轉導  新陳代謝  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Pig, Cow, Horse, )
產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量30kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human COMT:121-220/271 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Subcellular Location:
Isoform Soluble: Cytoplasm.
Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side.

Tissue Specificity:
Brain, liver, placenta, lymphocytes and erythrocytes.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the mammalian catechol-O-methyltransferase family.

SWISS:
P21964

Gene ID:
1312

Database links:

Entrez Gene: 1312 Human

Entrez Gene: 12846 Mouse

Entrez Gene: 24267 Rat

Omim: 116790 Human

SwissProt: P21964 Human

SwissProt: O88587 Mouse

SwissProt: P22734 Rat

Unigene: 370408 Human

Unigene: 704514 Human

Unigene: 100940 Mouse

Unigene: 220 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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