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磷酸化G蛋白偶合受體激酶2抗體
  • 產(chǎn)品貨號(hào)：
    BN40479R
  • 中文名稱：
    磷酸化G蛋白偶合受體激酶2抗體
  • 英文名稱：
    Rabbit anti-phospho-GRK2 (Ser670) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40479R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱phospho-GRK2 (Ser670)
中文名稱磷酸化G蛋白偶合受體激酶2抗體
別    名GRK2 (phospho S670); p-GRK2 (phospho S670); G-protein coupled receptor kinase 2; ADRBK 1; ADRBK1; Adrenergic beta receptor kinase 1; BARK 1; BARK; BARK1; Beta adrenergic receptor kinase 1; Beta ARK 1; Beta ARK1; G Protein Coupled Receptor Kinase 2; G protein dependent receptor kinase 2; FLJ16718; GRK 2; ARBK1_HUMAN.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量76kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human GRK2 around the phosphorylation site of Ser670:PR(p-S)PV 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq].

Function:
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Subunit:
Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1.

Tissue Specificity:
Expressed in peripheral blood leukocytes.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 PH domain.
Contains 1 protein kinase domain.
Contains 1 RGS domain.

SWISS:
P25098

Gene ID:
156

Database links:

Entrez Gene: 156 Human

Entrez Gene: 25238 Rat

Omim: 109635 Human

SwissProt: P25098 Human

SwissProt: Q99MK8 Mouse

SwissProt: P26817 Rat

Unigene: 83636 Human

Unigene: 254144 Mouse

Unigene: 13010 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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