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T細(xì)胞白血病淋巴瘤蛋白3抗體
  • 產(chǎn)品貨號：
    BN40495R
  • 中文名稱：
    T細(xì)胞白血病淋巴瘤蛋白3抗體
  • 英文名稱：
    Rabbit anti-TCL3/HOX11 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN40495R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推薦應(yīng)用：WB,ELISA

  • BN40495R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱TCL3/HOX11
中文名稱T細(xì)胞白血病淋巴瘤蛋白3抗體
別    名Homeo box 11 (T cell leukemia 3 associated breakpoint homologous to Drosophila Notch); Homeo box 11 (T cell lymphoma 3 associated breakpoint); Homeobox 11; Homeobox protein Hox 11; Homeobox protein Hox-11; Homeobox TLX-1; Hox-11; Hox11; MGC163402; OTTHUMP00000020816; Proto oncogene TCL 3; Proto-oncogene TCL-3; RGD1563655; T cell leukemia homeobox protein 1; T cell leukemia lymphoma protein 3; T-all, included; T-cell acute lymphocytic leukemia, included; T-cell leukemia 3 gene; T-cell leukemia homeobox protein 1; T-cell leukemia, homeobox 1; T-cell leukemia/lymphoma protein 3; TCL 3 proto oncogene; TCL3; Tlx-1; TLX1; TLX1_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  發(fā)育生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TCL3/HOX11:121-220/330 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. The Hox11 gene, termed an orphan homeobox gene, as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. The human Hox11 gene maps to chromosome 10q24 and has been implicated in the chromosomal translocation t(7;10)(q24;q11) that occurs in T-cell acute lymphoblastic leukemia (T-ALL). The t(7:10) translocation occurs between the Hox11 gene and the T-cell receptor (TCR) delta-chain gene and is a result of aberrant physiological recombinational events at the early stages of T-cell development. The Hox11 gene is normally expressed in the splanchnic anlage arising from the splanchnic mesoderm. Homozygous Hox11-deficient mice have no spleen, while all other splanchnic derivatives develop normally. Spleen development starts and proceeds normally in Hox11-deficient mice to a specific stage of embryogenesis, when the spleen anlage becomes fully absorbed.

Function:
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Subcellular Location:
Nucleus.

DISEASE:
Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.

Similarity:
Contains 1 homeobox DNA-binding domain.

SWISS:
P31314

Gene ID:
3195

Database links:

Entrez Gene: 3195 Human

Entrez Gene: 21908 Mouse

Entrez Gene: 499361 Rat

Omim: 186770 Human

SwissProt: P31314 Human

SwissProt: P43345 Mouse

SwissProt: D4A270 Rat

Unigene: 89583 Human

Unigene: 391203 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.