貨號(hào)
產(chǎn)品規(guī)格
售價(jià)
備注
BN40503R-100ul
100ul
¥2360.00
交叉反應(yīng):Mouse,Rat(predicted:Human,Dog,Cow,Sheep) 推薦應(yīng)用:IHC-P,IHC-F,ICC,IF,ELISA
BN40503R-200ul
200ul
¥3490.00
交叉反應(yīng):Mouse,Rat(predicted:Human,Dog,Cow,Sheep) 推薦應(yīng)用:IHC-P,IHC-F,ICC,IF,ELISA
產(chǎn)品描述
英文名稱 | SKOR2 |
中文名稱 | SKOR2蛋白抗體 |
別 名 | CORL2; Functional smad suppressing element 18; Functional Smad-suppressing element on chromosome 18; Fussel-18; FUSSEL18; Ladybird homeobox corepressor 1-like protein; LBX1 corepressor 1-like protein; SKI family transcriptional corepressor 2; SKOR2; SKOR2_HUMAN. |
研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
抗體來(lái)源 | Rabbit |
克隆類(lèi)型 | Polyclonal |
交叉反應(yīng) | Mouse, Rat, (predicted: Human, Dog, Cow, Sheep, ) |
產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù)) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 104kDa |
細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human SKOR2:871-970/1001 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
PubMed | PubMed |
產(chǎn)品介紹 | The sloan kettering virus (Ski) family of nuclear oncoproteins act as transcriptional regulators of TGF-β by interacting directly with SMAD proteins. Fussel-18 (functional Smad-suppressing element on chromosome 18), also known as SKOR2 (Ski family transcriptional corepressor 2), LBX1 corepressor 1-like protein, ladybird homeobox corepressor 1-like protein or CORL2, is a 1,001 amino acid protein that belongs to the Ski family. Localizing to nucleus as well as cytoplasm, Fussel-18 is expressed in cerebellum, spinal cord and testis. Fussel-18 acts as an antagonist to TGF-β in the nervous system, possibly by functioning as a transcriptional repressor of SMAD2 and SMAD3. Existing as two alternatively spliced isoforms, the gene encoding Fussel-18 maps to human chromosome 18q21.1 and mouse chromosome 18 E3. Function: Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Expressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at protein level). Similarity: Belongs to the SKI family. SWISS: Q2VWA4 Gene ID: 652991 Database links: Entrez Gene: 652991 Human SwissProt: Q2VWA4 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |